The purpose of the study was to investigate the moderated mediating effect of emotional schema through distress intolerance on the relationship between child abuse experience and non-suicidal self injury (NSSI). A total of 246 university students (59 men and 187 women) completed the following questionnaires: The Parent-Child Conflict Tactics Scale (PCCTS), The Functional Assessment of Self-Mutilation (FASM), Leahy Emotional Schema Scale II (LESS-II), and Distress Tolerance Scale (DTS). The main results were as follows. First, There was positive correlations between child abuse experience, emotional schema, distress intolerance, and non-suicidal self injury. Second, mediating model showed that the relationship between child abuse experience and non-suicidal self injury was fully mediated by distress intolerance. Third, using multiple regression and slope analysis, the moderation effect of emotional schema on the relationship between distress intolerance and NSSI was found. Finally, emotional schema also moderated the mediating effect of child abuse experience on NSSI through distress intolerance. These results suggest that emotional schema therapy would be considered as effective intervention for those who have child abuse experience and NSSI.