In this study, a metal oxide nanoparticles dispersed catalytic electrode was fabricated by alternating current plasma deposition approach. The fabrication involves the treatment of AC plasma on a precursor comprised of metal salts, namely CuCl₂, FeCl₂, and ZnCl₂, and a monomer (acrylic acid) in the presence/absence of a cross-linker. The utility of the fabricated electrodes has been demonstrated for the electrochemical determination of hydrogen peroxide (H₂O₂). The fabricated electrodes were characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscope (SEM), contact angle measurement, energy-dispersive X-ray spectroscopy (EDS), E-ray photoelectron spectroscopy (XPS) and cyclic voltammetry. Among the metal oxide modified electrodes prepared by the AC plasma deposition method, the copper oxide (CuO) nanoparticles catalytic electrode exhibited significant oxidation and reduction peaks for H₂O₂ in PBS solution. The catalytic electrode with CuO NPs exhibited a combination of good H₂O₂ sensing characteristics such as good sensitivity (63.52 mA M-1 cm-2), good selectivity, low detection limits (0.6 μM), fast sensing response (5 s), a wide linear range (0.5-8.5 mM), and good stability over 120 cycles. Based on our results, it is well demonstrated that plasma deposition could be effectively utilized for the fabrication of the catalytic electrode for detection of H₂O₂ concentrations. Further, the strategy of using AC plasma for fabrication of metal oxide based modified electrodes could also be extended for the fabrication of other kinds of nanomaterials-based sensors.