Title Page
Contents
1. Introduction 8
2. Material & Method 10
2-1. Participants 10
2-2. Study Outcomes 11
2-3. Haptoglobin Phenotyping 12
2-4. Statistical Analysis 14
3. Results 15
3-1. Baseline Characteristics. 15
3-2. Neurological Outcomes. 17
3-3. Cognitive Impairment 18
3-4. Analysis of Outcomes in Patients With Hp2-1 21
4. Discussion 23
5. Conclusion 27
6. Reference 28
7. Abstract (국문) 36
8. Abstract (영문) 38
Table 1. Demographic and clinical characteristics of patients with subarachnoid hemorrhge accoding to haptoglobin (Hp) phenotype. 16
Table 2. Multivariable logistic regression analysis of factors associated with 6-month poor outcomes and Cox proportional-hazards regression analysis of long-... 18
Table 3. Multivariable logistic regression analysis of variables associated with 6-month cognitive impairment and Cox proportional-hazards regression analysis... 20
Table 4. Multivariable logistic regression analysis of variables associated with poor outcome and cognitive impairment at 6 months, and Cox proportional-... 22
Figure 1. (A) Flow chart outlining the study protocol. (B) Western blotting analysis of haptoglobin (Hp) phenotype. 33
Figure 2. Kaplan-Meier survival curve illustrating the cumulative cognitive impairment-free survival probability according to haptoglobin phenotype (A) and subgroup analyses of patients... 34
Figure 3. (A) Western blotting analysis of haptoglobin (Hp) 2-1 for determination of relative α1 intensity. Albumin level is used as the reference value (B). Proposed mechanism of association with... 35