표제지
목차
Abstract 9
I. 서론 12
II. 재료 및 방법 18
1. 실험 재료 18
2. 표준품 및 시약 21
3. 표준 용액 제조 21
4. 중금속 분석방법 21
4.1. 납, 카드뮴, 비소 분석을 위한 전처리 및 분석기기 21
4.2. 수은 분석을 위한 전처리 및 분석기기 22
III. 결과 및 고찰 26
1. 분석법 검증 26
1.1. 직선성 26
1.2. 검출한계 및 정량한계 27
1.3. 회수율 32
2. 중금속 함량 분석 34
2.1. 약용 부위별 중금속 함량 36
2.2. 생약의 원산지별 중금속 함량 43
2.3. 수입 생약의 안전성 평가 46
IV. 요약 50
V. 참고문헌 52
Table 1. Classification of herbal medicines used samples. 20
Table 2. ICP/MS Conditions for heavy metal analysis. 24
Table 3. DMA-80 Conditions for heavy metal analysis. 25
Table 4. Linearity data of heavy metal from standard. 28
Table 5. The limit of detection (LOD) and limit quantification (LOQ) values of each heavy metal for standard. 31
Table 6. Recovery of heavy metal (μg/L) in spiking samples. 33
Table 7. The heavy metal acceptable concentration (mg/kg) in HMFD. 35
Table 8. Heavy metal contents (mg/kg) in herbal medicines classified by parts used. 39
Table 9. Heavy metal contents (mg/kg) in herbal medicines classified by parts used. 42
Table 10. Heavy metal contents (mg/kg) according to origin. 44
Table 11. Violation of heavy metal standards by year. 47
Table 12. Contents of heavy metal in herbal medicines circulating in Busan from 2019 to 2021. 49
Fig. 1. Origin classification of herbal medicines 19
Fig. 2. Calibration curves for determination of lead. 29
Fig. 3. Calibration curves for determination of cadmium. 29
Fig. 4. Calibration curves for determination of arsenic. 30
Fig. 5. Calibration curves for determination of mercury. 30