표제지
목차
요약 11
1. 서론 13
2. 실험방법 19
2.1. 전이량 평가 방법의 인공 소화액 조성 19
2.2. 생활화학제품 전이량 평가 대상 물질 21
2.3. 분석 전 전처리에 발생한 침전물에 대한 전처리 기술 수정 및 개선 24
2.3.1. 침전물로 인한 중금속 농도 영향 확인 실험 24
2.3.2. 침전물의 성분 분석 실험 26
2.3.3. 침전물 분리를 위한 필터 적용 가능성과 필터 재질 검토 26
2.4. 빠는 행위 및 빨고 침을 섭취하는 행위의 전이량 평가 기술 간소화 27
2.5. 전이량 분석 및 평가 방법 29
3. 결과 및 토의 30
3.1. 인공 소화액 내 질산 첨가로 인한 형성 된 침전물 30
3.1.1. 침전물로 인한 중금속 농도 영향 결과 31
3.1.2. 침전물 형성 원인 및 성분 분석 결과 32
3.1.3. 침전물 분리를 위한 필터 재질별 적용 가능성 결과 36
3.2. 생활화학제품 내 중금속 빠는 행위 전이량 평가 기술 간소화 결과 37
3.3. 개발된 전이량 평가 기술로 다양한 인증표준물질 전이량 평가 및 국립환경과학원 예규 제 611호의 전이량 평가 결과 비교 41
4. 결론 49
5. 참고문헌 52
6. 부록 58
Abstract 92
Table 1. Migration limits for toy safety guidelines in Europe Union 13
Table 2. Composition of artificial digestive fluid used in migration method 20
Table 3. CRM used to replace consumer chemical products migration 22
Table 4. CRM content list 23
Table 5. FTIR analysis conditions 26
Table 6. ICP-MS analysis conditions 29
Table 7. Collrelation results by filters material 36
Table 8. p-value (two-sided test) result of student's t-test by filter material 36
Table 9. Migration rate results using plastic type CRM of simplified suck model (S.T), suck and swallow model (S.S), suck model (S) 38
Table 10. Migration rate results using glass and paint type CRM of simplified suck model (S.T), suck and swallow model (S.S), suck model (S) 39
Table 11. Migration rate results using metals type CRM of simplified suck model (S.T), suck and swallow model (S.S), suck model (S) 40
Table 12. Probability of the transfer of heavy metals into the oral for each consumer chemical products plastic type for developed ingestion migration method and ingestion migration by Regulation No. 611 of NIER 43
Table 13. Probability of the transfer of heavy metals into the oral for each consumer chemical products glass and paint type for developed ingestion migration method and ingestion migration by Regulation No. 611 of NIER 44
Table 14. Probability of the transfer of heavy metals into the oral for each consumer chemical products metal type for developed ingestion migration method and ingestion migration by Regulation No. 611 of NIER 45
Table 15. Probability of the transfer of heavy metals into the oral for each consumer chemical products plastic type for simplified suck migration method and suck migration by Regulation No. 611 of NIER 46
Table 16. Probability of the transfer of heavy metals into the oral for each consumer chemical products glass and paint type for simplified suck migration method and suck migration by Regulation No. 611 of NIER 47
Table 17. Probability of the transfer of heavy metals into the oral for each consumer chemical products metal type for simplified suck migration method and suck migration by Regulation No. 611 of NIER 48
Fig 1. Migration method of oral gastric phase (UBM-G) and gastric and intestinal phase (UBM-GI) presented by UBM of BARGE 17
Fig 2. Migration method of oral suck phase (RIVM-S) and suck and swallow phase (RIVM-S.S) presented by suck model of RIVM 18
Fig 3. Test to determine the effect of heavy metals concentration due to precipitation 25
Fig 4. Simplified RIVM 'suck-model' migration method 28
Fig 5. UBM solution that has been digested until centrifugation (left), and the precipitate formed after adding HNO₃ in the solution that has been... 30
FIg 6. The ratio of the filter concentration and the total content concentration of the sample in which the precipitate was formed 31
Fig 7. FITR results of precipitate formed after the addition of nitric acid in artificial digestive fluid containing no heavy metals 32
Fig 8. After nitric acid to the enzyme components in the composition of artificial digestive fluid 33
Fig 9. FTIR result of enzymes components in artificial digestive fluid composition 34
Fig 10. Developed ingestion migration and simplified suck migration method for consumer chemical products in heavy metals 51