Title Page
Contents
Abstract 7
I. INTRODUCTION 8
II. MATERIALS AND METHODS 10
A. MRONJ Animal Model 11
B. Administration of PH-altering Agents 12
1. Alkalotic Group 12
2. Acidotic Group 13
3. Control Group 13
C. Animal Sacrifice and Arterial Blood Gas Analysis 13
D. Macroscopic and Radiographic Analysis 13
E. Histomorphometric Assessment 14
F. Statistical Analysis 15
III. RESULTS 16
A. Arterial Blood Gas Analysis 16
B. MRONJ Progression 16
C. Micro-CT Analysis 17
D. Histomorphometric Analysis 17
IV. DISCUSSION 20
V. CONCLUSION 22
References 23
국문초록 27
Table 1. MRONJ Progression 16
Figure 1. Research Design. 11
Figure 2. Surgical Intervention. 12
Figure 3. Determination of Volume/Region of Interest (A) and segmentation in, micro-CT... 14
Figure 4. Representative images of group 1 (1a, 1b, c); group 2 (2a, 2b, 2c) and control (3a, 3b,... 18
Figure 5. Histomorphometric evaluation among group 1 (NaHCO₃), group 2 (NH₄Cl) group and... 19