Title Page
국문초록
Contents
I. Introduction 9
II. Materials and Methods 11
Patients 11
Active Surveillance 11
Bacterial isolation 11
Genotyping of VRE 11
Identification and susceptibility testing 12
Molecular epidemiology 12
Risk factor analysis 12
Statistical methods 13
III. Results 14
Prevalence of VRE colonization 14
Genotyping 14
Identification of VRE 14
Pattern of Antimicrobial Resistance 14
ST of vancomycin-resistant E. faecium 15
VRE colonization and clinical characteristics 15
IV. Discussion 16
References 30
Abstract 35
Table 1. Prevalence of vancomycin-resistant Enterococcus spp (VRE) by chromogenic agar-based culture method and multiplex PCR-based method 21
Table 2. Antimicrobial susceptibility of 37 vancomycin-resistant E. faecium isolates 22
Table 3. Genotypic characteristics of vancomycin-resistant E. faecium isolates based on multilocus sequence typing 23
Table 4. Antimicrobial susceptibility of 37 VRE isolates stratified by MLST 24
Table 5. Clinical characteristics of 28 vancomycin resistant E. faecium isolates stratified by MLST 25
Table 6. Clinical differences between VRE-colonized group and-uncolonized group 26
Table 7. Univariate analysis of risk factors for VRE colonization 27
Table 8. Logistic regression of risk factors for VRE colonization 28
Figure 1. Multiplex PCR for the vanA and vanB. 29