The 2,4-Dienoyl CoA reductase1 gene (DECR1) is associated with carcass and meat quality traits in cattle. 2,4-Dienoyl CoA reductase 1 (DECR1) located on BTA14. 2,4-Dienoyl CoA reductase1 (DECR1) is a nuclear encoded mitochondrial enzyme that participates in the β-oxidation pathway by catalyzing the reduction of trans-2-cis-4-dienoyl-CoA to 3-enoyl-CoA (Kunau and Dommes, 1978). The transcription unit of the human DECR1 gene includes 10 exons and nine introns of variable size that span 30 kb (Helander et al, 1997). The deficiency of this enzyme in human has been associated with the presence of 2-trans-4-cis-decadienoylcarnitine, a metabolite produced by incomplete oxidation of the linoleic acid in urine and blood of the affected patients (Roe et al, 1990).
The objective of this study was to identify SNP in Hanwoo DECR1 gene to detection of Novel Mutations the effect of the SNP on economic traits. In this study is direct DNA sequencing analysis in 200 Hanwoo population.
Genetic polymorphism was screened by DNA sequencing detected a nucleotide in exon 1 SNP of DECR1 gene. All are missense mutations that exists in exon. So DECR1 gene mutation is four mutation creates a new discover and the other is two mutation in reported mutation.
Total 2 SNPs were found and G20788A(GTG:Val → ATG:Met), A23262G(ATA:Ile → GTA:Val) SNPs of them detected in coding region. It will be possible to use SNP markers on selecting to the carcass and meat quality traits of the Hanwoo, which is the meat quality traits.