표제지
요약
Abstract
목차
I. 서론 11
II. 대상 및 방법 13
1. 대상 13
2. 방법 13
1) 복강내 약물 주입 13
2) 척수강 내 카테터 삽입 14
3) 족저 절개 14
4) 통증행동검사 15
5) 운동 장애 검사 15
6) 진정 효과 검사 16
7) 실험 구성 17
i) 복강 내 ethosuximide와 mibefradil 투여 17
ii) 척수강 내 ethosuximide와 mibefradil 투여 18
8) 통계 분석 19
III. 결과 20
1. 복강 내로 투여된 Ethosuximide의 효과 20
2. 복강 내로 투여된 Mibefradil의 효과 20
3. 척수강 내로 투여된 ethosuximide의 효과 21
4. 척수강 내로 투여된 mibefradil의 효과 21
5. 운동 기능과 진정 작용에 대한 Ethosuximide와 Mibefradil의 효과 21
IV. 고찰 30
V. 결론 34
참고문헌 36
감사의 글 42
Fig. 1. The time course of the antihyperalgesic effects (percent maximal possible effect [%MPE]) of intraperitoneal ethosuximide in rats received plantar incision of hindpaw. 22
Fig. 2. Dose response curves of intraperitoneal ethosuximide and mibefradil on antihyperalesic effect expressed as peak percent maximal possible effect (%MPE). 23
Fig. 3. The time course of the antihyperalgesic effects (percent maximal possible effect [%MPE]) of intraperitoneal mibefradil in rats received plantar incision of hindpaw. 24
Fig. 4. The time course of the antihyperalgesic effects (percent maximal possible effect [%MPE]) of intrathecal ethosuximide in rats received plantar incision of hindpaw. 25
Fig. 5. Dose response curves of intrathecal ethosuximide and mibefradil on antihyperalesic effect expressed as peak percent maximal possible effect (%MPE). Each point 26
Fig. 6. The time course of the antihyperalgesic effects (percent maximal possible effect [%MPE]) of intrathecal mibefradil in rats received plantar incision of hindpaw. 27
Fig. 7. Dose response curves for motor block (percent maximal possible effect [%MPE]) of ethosuximide or mibefradil, intraperitoneally(a) and intrathecally(b). Each point 28
Fig. 8. Dose response curves for sedation effect (percent maximal possible effect [%MPE]) of ethosuximide or mibefradil, intraperitoneally(a) and intrathecally(b). 29