목차
Ⅰ. 緖論 9
Ⅱ. 材料 및 方法 11
1. 實驗動物 11
2. 群 分離 11
3. 順氣和中湯의 造成 12
4. 藥物調劑 12
5. 藥物의 投與 13
6. Indomethacin에 의한 胃潰瘍 誘發 14
7. 潰瘍病巢의 數 및 크기의 測定 14
8. 組織標本의 製作 및 觀察 14
9. 壁細胞 및 主細胞의 數的 變化 15
10. Grimelius 陽性反應細胞의 數的 變化 15
11. Serotonin 陽性反應細胞의 數的 變化 15
12. 統計處理 16
Ⅲ. 結果 17
1. 潰瘍病巢의 數的 變化 17
2. 潰瘍病巢크기의 變化 19
3. 組織學的 變化 21
1) 潰瘍病巢 組織 21
2) 潰瘍病巢 周邊組織 22
3) Grimelius 陽性細胞 23
4) Serotonin 陽性細胞 24
4. 壁細胞의 數的 變化 24
5. 主細胞의 數的 變化 33
6. Grimelius 陽性反應細胞의 數的 變化 35
7. Serotonin 陽性反應細胞의 數的 變化 37
Ⅳ. 考察 39
Ⅴ. 結論 46
參考文獻 48
英文抄錄 58
Table 1. Experimental design in this study 12
Table 2. Composition of Sunkiwhajung-tang used in this study 13
Table 3. Changes of number of ulcerative lesions after Sunkiwhajungtang administration 18
Table 4. Changes of size of ulcerative lesions after Sunkiwhajungtang administration 20
Table 5. Histological scores in the ulcerative lesions after Sunkiwhajungtang administration 22
Table 6. Histological scores in the peri-ulcerative lesions after Sunkiwhajungtang administration 23
Table 7. Changes of parietal cell number in the peri-ulcerative lesions after Sunkiwhajung-tang administration 25
Table 8. Changes of chief cell number in the peri-ulcerative lesions after Sunkiwhajung-tang administration 34
Table 9. Changes of Grimelius-positive cell number in the periulcerative lesions after Sunkiwhajung-tang administration 36
Table 10. Changes of Serotonin-positive cell number in the periulcerative lesions after Sunkiwhajung-tang administration 38
Graph 1. Changes of number of ulcerative lesions after Sunkiwhajungtang administration 18
Graph 2. Changes of size of ulcerative lesions after Sunkiwhajungtang administration 20
Graph 3. Changes of number parietal and/or chief cells in the periulcerative lesions after Sunkiwhajung-tang administration 34
Graph 4. Changes of number Grimelius-positive cells in the peri-ulcerative lesions after Sunkiwhajung-tang administration 36
Graph 5. Changes of number Serotonin-positive cells in the peri-ulcerative lesions after Sunkiwhajung-tang administration 38
Fig 1. Histological profiles of ulcerative lesions after Sunkiwhajungtang administration 26
Fig 2. Histological profiles of peri-ulcerative lesions (low magnification) after Sunkiwhajung-tang administration 27
Fig 3. Histological profiles of peri-ulcerative lesions (high magnification) after Sunkiwhajung-tang administration 28
Fig 4. Histological profiles of Grimelius-positive cells (low magnification) after Sunkiwhajung-tang administration 29
Fig 5. Histological profiles of Grimelius-positive cells (high magnification) after Sunkiwhajung-tang administration 30
Fig 6. Histological profiles of Serotonin-positive cells (low magnification) after Sunkiwhajung-tang administration 31
Fig 7. Histological profiles of Serotonin-positive cells (high magnification) after Sunkiwhajung-tang administration 32