감사의 글
목차
Ⅰ. 서론 10
Ⅱ. 재료 및 방법 16
1. 재료 16
2. 기기 및 시약 16
3. Gel emulsion의 안정화 17
1) Gel emulsion의 제조 처방 17
2) Gel emulsion의 제조방법 17
3) Lamella liquid cystal의 phase diagram 작성 19
4) Oil phase첨가에 따른 액정상의 변화 및 유변학적 특성 19
5) Water phase첨가에 따른 emulsion 입자 변화 24
6) Gel emulsion에 따른 안정도 평가 24
(1) 조건별 경시적 변화 확인 24
(2) 현미경 관찰 24
(3) 원심분리에 따른 확인 24
4. 피부 친화력 측정 실험 28
1) 피부 수분 함유량 및 유분 함유량 측정 28
2) 수분 증발량 측정 28
5. Gel emulsion의 안전성 실험 28
1) 첩포 시험 28
Ⅲ. 결과 및 고찰 33
1. Gel emulsion의 안정화 실험 33
1) Lamella liquid cystal의 phase diagram 작성 33
2) Oil phase첨가에 따른 액정상의 변화 및 유변학적 특성 34
3) Water phase첨가에 따른 emulsion 입자 변화 39
4) Gel emulsion에 따른 안정도 평가 39
(1) 조건별 경시적 변화 확인 39
(2) 현미경 관찰 42
(3) 원심분리에 따른 확인 42
2. 피부 친화력 측정 실험 46
1) 피부 수분 함유량 및 유분 함유량 측정 46
2) 수분 증발량 측정 46
3. Gel emulsion의 안전성 실험 50
1) 첩포 시험 50
Ⅳ. 요약 52
Ⅴ. 참고문헌 53
Ⅵ. 초록 57
Ⅶ. Abstract 59
Table 1. The exper imental for mulation for lamella liquid crystal gel 18
Table 2. Final for mulation of gel emulsion 20
Table 3. Physical and chemical proper ty of var ious oil 22
Table 4. The expr ession method of patch test 32
Table 5. Change in r heological pr oper ties with increasing oil contents 38
Table 6. Change in emulsion droplet size with addition of water 41
Table 7. Result for patch test of gel emulsion 51
Fig. 1. Schematic representation of simple O/W emulsion 12
Fig. 2. Schematic representation of simple W/O emulsion 13
Fig. 3. Schematic representation of W/O/W multiple emulsion 14
Fig. 4. Schematic representation of simple lamella liquid crystal 15
Fig. 5. The process of preparation for gel emulsion 21
Fig. 6. The procedure of measurement for rheological properties novel emulsion 23
Fig. 7. The procedure of gel emulsion condition 25
Fig. 8. The obser vation of gel emulsion stability by centrifuge 26
Fig. 9. The obser vation of gel emulsion by microscope 27
Fig. 10. The relative content of oil and water on the skin novel emulsion 29
Fig. 11. The relative water loss of each emulsion at drying condition 30
Fig. 12. The procedure for patch test of gel emulsion 31
Fig. 13. Ter nary phase diagram 35
Fig. 14. The cross―polarized light microscopic photography of lamella liquid crystal (×400) 36
Fig. 15. Change in lamella structure with increasing oil contents 37
Fig. 16. The ternary phase diagram for novel emulsion 40
Fig. 17. Comparison of gel emulsion and O/W emulsion in incubator for 3, 7, 15, 30 days (70℃) 43
Fig. 18. Microscopy photograph of novel gel emulsion (�400) 44
Fig. 19. Comparision of gel emulsion and O/W emulsion in centrifuge (18000 � g) 45
Fig. 20. Comparison of water contents in skin by various time 47
Fig. 21. Comparison of oil contents in skin by various time 48
Fig. 22. The relative content of water loss for emulsion by various time at 45℃ 49