표제지
Acknowledgement
목차
Abstract 5
Introduction 6
Materials and Methods 9
1) Plasmids 9
2) Yeast two-hybrid assay 9
3) Mammalian two-hybrid assay 10
4) GST pull-down assay 10
5) In vitro degradation assays 11
6) Transient transfection and CAT ELISA 11
Results 13
1) HPV E7 protein interacts with IRF-1 13
2) HPV E7 abrogates the transactivation function of IRF-1 15
3) pRb-binding motif of E7 is essential for the transrepression of IRF-1 function 19
4) How HPV E7 inactivates IRF-1 19
Discussion 28
References 33
영문 논문 제출서 40
영문 인준서 41
초록 42